The Effects of Environmental Education on Residents' Ecological Security Behavior: The Mediating Role of Nature's Psychological Ownership Perspective and The Moderating Role of Visual Fluency.

Residents are one of the most significant stakeholder groups in ecologically vulnerable regions, and the local ecological environmental governance efforts require their active cooperation and participation. To this end, this study leverages the sampled survey data from residents across 14 cities in Guangxi, China, and uses a structural equation modeling analysis to explore the impact of environmental education perception on residents' ecological security behavior. The results indicate that psychological ownership of nature plays a positive mediating role between environmental education perception and residents' ecological security behavior, as well as between ecological consciousness and residents' ecological security behavior, thereby supporting the idea that a sense of stewardship in protecting ecological security is a key factor in residents' conversion of their ecological protection cognition into practical actions. Further research finds that visual fluency has a moderating effect on the relationship between environmental education perception and psychological ownership of nature. This study provides new insights into the theoretical understanding of the formation mechanism of residents' ecological security behavior, enriches the theory of psychological ownership, and offers policy recommendations for governments implementing ecological environmental propaganda programs.

Positive Verbal Rewards, Creative Self-Efficacy, and Creative Behavior: A Perspective of Cognitive Appraisal Theory.

The creative behavior of cultural innovation team members is the key to driving the team forward. Previous studies have relatively neglected the dynamic mechanism of positive verbal rewards on the creative behavior of cultural innovation team members. This paper, drawing on cognitive appraisal theory, focuses on the dynamic mechanism of positive verbal rewards on the creative behavior of cultural innovation team members and the moderating effect of positive affectivity. Based on the survey of 211 cultural innovation team members in Guangdong, China, this paper constructs a relationship model between positive verbal reward, creative self-efficacy, positive affectivity, and members' creative behaviors and empirically tests the model. The results of statistical data analysis show that positive verbal reward has a significant positive impact on members' creative behavior. Creative self-efficacy partially mediates between positive verbal rewards and members' creative behavior; positive affectivity moderates the positive influence of creative self-efficacy on members' creative behavior. The higher the level of positive affectivity, the stronger the positive impact of positive verbal rewards on members' creative behavior, and vice versa. The above research findings help clarify the mechanism of positive verbal rewards on the cultural innovation team members' creative behaviors in the context of Chinese organizations and provide theoretical support for cultural innovation team management practices.

Current status of health standards and health management system in childcare institutions / 中国学校卫生

Abstract@#Children in childcare institutions are involved with a high degree of contact, poor personal hygiene habits, low resistance, high incidence of disease, infections diseases are easily spread without proper public health management. Compared with child care centers, the construction of national standards, industry standards and management systems for primary and secondary school health is relatively complete, while the applicability of the current hygiene standards and management systems for childcare centers is worth exploring. By reviewing the previous literature, the study sorted out the current status of hygiene standards and hygiene management system in childcare institutions, and assesse their applicability in childcare institutions, so as to provide references for the establishment of hygiene standards and hygiene management system in childcare institutions.

Nanocrystals embedded in chitosan-based respirable swellable microparticles as dry powder for sustained pulmonary drug delivery.

In this study, nanocrystals embedded in microparticles were designed to achieve sustained pulmonary drug delivery of hydrophobic drugs. Chitosan based microparticles were engineered to allow sustained drug release via swelling and mucoadhesive properties of the polymer. Taking cinaciguat as a hydrophobic model drug, drug nanocrystals were prepared by high pressure homogenization and then encapsulated in chitosan microparticles via spray drying. Through various in vitro characterizations, it was shown that drug loaded microparticles had a high drug loading with promising aerosolization characteristics (mean volume diameter (Dv50) 3-4µm, experimental mass mean aerodynamic diameter (MMADe) 4-4.5µm, fine particle fraction (FPF%) 40-45%, emitted dose (ED%) 94-95%). The microparticles showed high swelling capacity within 5min, with various sustained drug release rates depending on chitosan concentration and molecular weight. Furthermore, aerosolization performances under various inhalation conditions were investigated. It was found that both inspiratory flow rate and volume had an influence on the aerosolization of developed microparticles, indicating actual inhalation efficiency might be compromised under disease conditions. Taken together, in vitro data indicate that chitosan based swellable microparticles could potentially be useful as nanocrystal carrier to achieve sustained pulmonary delivery. To complete the feasibility assessment of this formulation principle, future in vivo safety and efficacy studies are needed.

Recent advances in controlled pulmonary drug delivery.

Characterized by large surface area, high vascularization and thin blood-alveolar barrier, drug delivery by the pulmonary route has benefits over other administration routes. However, to date most of the marketed inhalable products are short-acting formulations that require the patient to inhale several times every day, thus reducing patient compliance. Controlled pulmonary drug delivery is a promising system but the formidable airway clearance mechanisms need to be avoided. This review mainly introduces the barriers impeding the development of controlled pulmonary drug delivery and strategies used to overcome them. We believe that large porous particles, swellable microparticles and porous nanoparticle-aggregate-based particles are the most promising carriers to control drug release in the lung.

[Preparation of budesonide sustained-release dry powder for inhalation and influence of lactose content].

Using high pressure homogenization method combined with spray-drying, budesonide-loaded chitosan microparticles were prepared and the in vitro release profile was investigated. The microparticles were then blended with lactose using a vortex mixer, influence of mixing speed, mixing time on drug recovery rate and content homogeneity were investigated. Meanwhile, influence of lactose content on drug recovery rate, content homogeneity, powder flowability and in vitro deposition were studied. It turned out that budesonide was released from the microparicles in a sustained manner, with fine particle fraction as high as 46.0%, but the powder flowability was poor. After blending with 10 times of lactose, the drug recovery rate was 96.5%, with relative standard deviation of drug content 2.5%, and fine particle fraction of the formulation increased to 59.6% with good flowability. It's demonstrated that using a vortex mixer, budesonide sustained-release dry powder for inhalation with good recovery and content homogeneity could be prepared, the formulation had good flowability and was suitable for pulmonary inhaling.